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Nakon primena visokih doza često je zabeleženo zadržavanje vode i natrijuma, ovo se smatra posledicom povišene produkcije androgena.Takođe, višestruka trudnoća i karakteristike roditelja podvrgnutih lečenju steriliteta (npr. starost majke, karakteristike spermatozoida) mogu biti udružene sa povišenim rizikom za pojavu kongenitalnih anomal